II. Textbooks and/or Equipment/Supplies
    Tamarin, Robert, 2003.Principles of Genetics,
    7^th edition,WCB McGraw-Hill.

    Wellnitz, William R. 1995 GENETICS Problem Solving Guide
    2^nd edition,WCB McGraw-Hill

III. Course Description from Catalog
     An introduction to the mechanisms of inheritance,
     cytoplasmic inheritance,population genetics and molecular
     genetics, which includes mechanisms of recombination
     mutation and cancer.

IV. General Education Areas Met:
     This course contributes to the fulfillment of the following
     General Education Requirements:
     "2" Communication
     "3" Critical Thinking
     "5" Mathematics
     "6" Science
     "7" Technology
     Each General Education Requirement fulfillment is indicated
     by number in course goals.

V.  Goals and Objectives
       Upon the completion of each course unit, students
       will/shall be able to:

    A. Explain the cellular basis of inheritance and relate
       cell division to reproduction. ("2", "3" "6", "7")

       1. describe the prokaryotic chromosome and the process of
          binary fission.
       2. describe a duplicated eukaryotic chromosome, and
          distinguish between diploid and haploid.
       3. state the difference between chromatin and
          chromosome, and explain how one becomes the other.
       4. describe the cell cycle, how it is controlled and
          contrast normal cell behavior with that of cancer
          cells.
       5. describe the stages of mitosis and also cytokinesis
          in plant and animal cells.
       6. give an overview for the process of meiosis and its
          stages, and state its role in plant and animal life
          cycles.
       7. describe the stages of meiosis in detail, and
          describe synapsis and tell how crossing-over
          occurs.
       8. compare the process of meiosis to mitosis.
       9. describe sexual reproduction and the manner in
          which it brings about genetic variation.
   B.  Explain the classic mechanisms of inheritance.
         ("2", "3" "6", "7")

      10. describe Mendel's methods and results in his
          monohybrid and dihybrid experiments.
      11. state Mendel'sLaw of Segregation and explain
          with examples.
      12. state Mendel'sLaw of Independent Assortment
          and explain with examples.
      13. explain the use of the testcross to determine
          genotype
      14. solve one trait and two trait genetics problems
          through the use of Punnett squares or the laws of
          probability.

  C.  Explain the classic mechanisms of inheritance
      that extend beyond Mendel.  ("2", "3" "6", "7")

      15. recognize and solve problems involving multiple  alleles,
          incomplete dominance, codominance, epistatic genes,
          pleiotropic genes and lethal genes.
      16. describethe determination of sex and explain
          sex (X) linked inheritance
      17. solve sex(X) linked problems and sex influenced
          problems.
      18. explain linked genes and solved linked genes problems
      19. using the results of linked gene crosses determine the
          map distance of the genes on the chromosome.
      20. describe the preparation of a human karyotype and
          how to use it.
      21. describe variations in chromosome structure through
          inversions, deletions and translocations.
      22. describe chromosomal abnormalities, aneuploidy,
          and polyploidy and give examples.
      23. recognize the patterns of inheritance when viewing a
          human pedigree chart.
      24. name and describe the method of mapping a human
          chromosome.

  D.  Explain how genetic information stored in DNA molecules
      is used to assemble protein molecules.("2", "3" "6", "7")

      25. describe the history of the chemistry of the gene.
      26. describe the Watson and Crick Model of DNA and
          Chargaff's rule.
      27. describe the mechanism and enzymology (helicase, primase,
          DNA polymerase, DNA ligase) of DNA replication.
      28. contrast DNA replication in procaryotes and
          eucaryotes.
      29. describe the structure of RNA and give the
          function of three RNA subtypes.
      30. state the Central Dogma of molecular biology.
      31. describe the method of transcription
      32. describe the method of post-transcriptional
          modification in the nucleus.
      33. describe the control of transcription include the
          operon model.
      34. explain the codon as triplet, degenerate and
          universal.
      35. describe the mechanism of translation and furnish
          the details of initiation, elongation, and
          termination.

  E.  Explain the inheritance of prokaryotic cells
      and and viruses. ("2", "3" "6", "7")

      36. categorize and describe bacterial phenotypes.
      37. describe the lytic and lysogenic cycle
          in bacteriophage.
      38. describe transformation, conjugation, and transduction.
      39. describe how conjugation (interrupted mating)
          is used in prokaryotic mapping.
      40. give the correct sequence of the events in the
          replication of DNA and RNA animal viruses.

  F.  Describe the control of gene expression at the
      transcriptional level in prokaryotes.("2", "3" "6", "7")

      41. describe transposons and transposable elements.
      42. describe the Operon Model (inducible system
          for prokaryotic control
      43. describethe Operon Model (repressible system).

  G.  Explain some of the currenttechniques used for
      DNA technology. ("2", "3" "6", "7")

      44. describeDNA cloning, restriction endonucleases,
          palindromes, vectors and genomic libraries.
      45. describereverse transcription in forming cDNA.
      46. describethe techniques in application of gene probes.
      47. describethe polymerase chain reaction (PCR).
      48. describethe Sanger (dideoxy) method of DNA sequencing.
      49. describethe method of DNA fingerprinting, including
          RFLP, electrophoresis and Southern Blotting.
      50. definea transgenic organism.
      51. describethe "Human Genome Project" and give the rational
          for the undertaking.

  H.  Explain the organizational level of the eukaryotic
      chromosome,the control of gene expression and mutations.
      ("2", "3""6", "7")

      52. describethe eukaryotic chromosome and the nature
          of the centromere and telomere.
      53. describethe repetitive nature of DNA.
      54. explainthe genes of myoglobin and hemoglobin.
      55. describe the mechanism of antibody diversity.
      56. contrast spontaneous versus induced mutations and
          describe the methods of mutagen detection
          (fluctuation test and Ames test}.
      57. compare frameshift mutation and point mutations.
      58. describe the mechanisms of DNA repair.

  I.  Explain quantitative ineritance. ("2", "3" "6", "7")
      59. describe continuous traits, and polygenes and
          solve problems of polygenic inheritance.
      60. explainthe role of the environment onn phenotype

  J.  Understand the concept of population level genetic processes.
      ("2", "3""6", "7")

      61. describe the Hardy-Weinberg equilibrium
      62. calculate allelic frequencies from phenotypic
          distribution.
      63. list the five assumptions of the Hardy-Weinberg
          equilibrium.
      64. be ableto use chi square analysis to determine if a
          population fits the Hardy-Weinberg equilibrium.
      65. describe the process that change allelic
                        frequencies.
      66. Contrast and give examples of genetic drift, gene
          flow and natural selection.

VI. Expected Student Outcomes
    During the semester you will be assessed for learning outcomes.
    Some questions in the final exam will be used for assessment.
    Students will applythe scientific method of inquiry to problem
    solving.

VII. Instructional Methodology
     A. Textbook readings and problems.
     B. Internet PowerPoint presentations will be available online
       at Blackboard. Registered students receive an account
       and login for Blackboard.
     C. Material is also available on Genetics 212 LMC web.
       (http://www.lmc.cc.mi.us/liberal/bio/bio212/g212_frame.html)
       No login required except for gradebook.
     D. Instuctor will be available for questions by email.

VIII.   Writing Across The CurriculumStrategy
       Students are expected to write essay exam answers using
       appropriate grammar, sentence structure and spelling.
       Critical Thinking Skills in the scientific method will
       be emphasized and assessed.

IX. Grading CriteriaAnd Requirements
    For a student toget credit and a letter grade, he/she must
    take exams and quizzesat scheduled times and achieve the minimum
    level scores on these tests as indicated in the grading scale.

A. The Exams are as follows:

      1. The hourly Exams will be (on campus on Thursdays at 7PM)
        100 points and will consist of objective, fill in the blank
        and essay type questions. Note dates on Tentative Lecture
        schedule. The questions are taken from the objectives outlined
        in this syllabus. If you can't make the campus dates,
        arrangements should be make with instructor for other
        times or other apporved sites with a proctor.

      2. On Line quizzes will count no more than 20 points
        each, and the format will include one or more of
        the following: objective, fill in the blank,
        problem solving, or essay. The questions are taken
        from the objectives outlined in this syllabus.

      3. A comprehensive final 100 point test will conclude
        the course and will include objectives from all units
        but specifically from the last unit.  The format
        includes 100 multiple choice, matching  and/or true
        and false questions.

X. Grading Scale

A. Summary of tests and points.
   1. Hourly exams (3)         300 pts.
   2. Quizzes (4 to 6)          80 pts.
   3. Final Exam              100 pts.
       TOTAL POINTS           480 pts.

C. See "Grading" policy in the College Catalog.

       A missed exam not made up will be counted as zero
       points.It is the student's responsibility to
       be available for the make up at the time arranged.

IX. Attendance Policy/Withdrawal Policy

A. The class attendance policy is the sameas the college
   policy as stated in the CollegeCatalog.
   "It is consistent with the collegephilosophy that
   regular class attendance is necessaryif the student
   is  toreceive maximum benefits from the course. Students
   are expected to attend everyclass and laboratory  period
   for which they have registered."
   "Two weeks of consecutive absencesor failure to attend
   20% of the scheduled semestercontact hours for a  class,
   makes a student subject to dismissalfrom the  class at
   the option of the instructor."

B. Mindful of the diverse student body that Lake Michigan
   college serves, and the varied belief systems that its
   students represent, the Collegewill make a reasonable
   effort to accommodate students who need to be excused
   from classes for the observance of religious holidays.
   This policy does not apply to students who knowingly
   register for classes scheduled to meet on days that
   consistently conflict with their day of worship, e.g.,
   a student who signs up for Saturday classes when the
   student normally worships on Saturday.

C. Dropping the Course The college withdrawalpolicy is
   stated in the College Catalog.
   The current college policy is that "Students who withdraw
   from class through the twelfthweek of the  semester
   (five weeks in spring or summersession) will  be assigned
   a grade of W. Beyond the twelfth week of  the semester,
   students who withdraw will be assigned a  grade of E."
   The last day to withdraw fromclass is  April 12, 2001.

DATE       TOPIC                         READING* ASSIGNMENT

       I CELLULAR BASIS OF INHERITANCE         (7th edition)

Week 1   Introduction                        Ch. 1
         Cell cycle, mitosis and meiosis     Ch. 3
     2   Mendelian Principles                Ch. 2
         Probability and Punnett squares

       II MENDELIAN EXTENSIONS
     3   Multiple alleles/Epistasis          Ch. 2
         Sex determination/Sex Linkage       Ch. 5

Feb  6    Exam 1 - 100pts

Week 5   Linkage and chromosomalmapping      Ch. 6
         Cytogenetics                        Ch. 8

       III MOLECULAR GENETICS
     6   The Gene/DNA replication            Ch. 9
         Gene Expression/transcription       Ch. 10
         Gene Expression/Translation         Ch. 11

Mar 6     EXAM 2 - 100pts.

Mar 10 - 16 Spring Break -

Week 9   Genetics of bacteria& Viruses       Ch. 7
    10   Prokaryotic Control  Operons/Transposons      Ch.   14
    11   Recombinant DNA Technology          Ch. 13
    12   Recombinant DNA Technology          Ch. 13

Apr 10    Exam 3 100 pts.

Week 13  Eukaryotic chromosome               Ch. 16
                     Immunogenetics                                                    Ch. 16
         DNA Mutation and Repair             Ch. 12

                IV Population Genetics
     14  Variationsand frequencies          Chs. 18,19, 20
         Hardy-Weinberg Principle

May 1    Comprehensive Final Exam - 100 pts

  *Tamarin, Robert, 2003, Principles of Genetics, McGraw-Hill

DATE       TOPIC                         READING* ASSIGNMENT

       I CELLULAR BASIS OF INHERITANCE         (6th edition)

Week 1    Introduction                        Ch. 1
         Cell cycle, mitosis and meiosis      Ch. 3
     2   Mendelian Principles                 Ch. 2
         Probability and Punnett squares

       II MENDELIAN EXTENSIONS
     3   Multiple alleles/Epistasis           Ch. 2
         Sex determination/Sex Linkage        Ch. 5

Feb  6    Exam 1 - 100pts

Week 5    Linkage and chromosomal mapping     Ch. 6
          Cytogenetics                        Ch. 8

       III MOLECULAR GENETICS
     6   The Gene/DNA replication             Ch. 9
         Gene Expression/transcription        Ch. 10
         Gene Expression/Translation          Ch. 11

Mar 6     EXAM 2 - 100pts.

Mar 10 - 16 Spring Break -

Week 9    Genetics of bacteria& Viruses       Ch. 7
    10    Prokaryotic Control  Operons/Transposons      Ch.   13
    11    Recombinant DNA Technology          Ch. 12
    12    Recombinant DNA Technology          Ch. 12

Apr 10    Exam 3 100 pts.

Week 13   Eukaryotic chromosome                Ch. 14
                        Immunogenetics                                                      Ch. 15
          DNA Mutation and Repair              Ch. 16

               IV Population Genetics
     14   Variations and frequencies          Chs. 18,19, 20
          Hardy-Weinberg Principle

May 1     Comprehensive Final Exam - 100 pts